The ultimate guide to mixing skincare ingredients

hands holding a skin cream on a leaf in a laboratory

Mixing skincare products-the basics

If you’re like me, you love trying out new skincare ingredients and products. Whether it’s a new face mask or a serum that promises to banish wrinkles, I’m always game to experiment. But there’s one thing I never do when trying out new products: mix and match ingredients.

Why? Because as anyone who’s taken a basic chemistry class knows, certain ingredients don’t play well together. In the world of skincare, that can mean everything from irritation and redness to breakouts and even burns. So, before you start mixing and matching your skincare products, take a look at this guide to see which ingredients should (and shouldn’t) be mixed.

Skincare ingredients that go together

Hyaluronic acid and vitamin C
Hyaluronic acid is a moisture-binding ingredient that helps keep skin hydrated and plump. Vitamin C is an antioxidant that brightens skin and reduces the appearance of wrinkles. When used together, these two ingredients work synergistically to give you brighter, more youthful-looking skin.

Glycolic acid and vitamin C
Glycolic acid is an exfoliating ingredient that helps improve the appearance of fine lines, wrinkles, and dark spots. Vitamin C is an antioxidant that brightens skin and reduces the appearance of wrinkles. When used together, these two ingredients help create brighter, more even-toned skin.

Skincare ingredients that shouldn’t be combined

Benzoyl peroxide and salicylic acid
Benzoyl peroxide is an acne-fighting ingredient that kills bacteria and dries up excess oil. Salicylic acid is an exfoliating ingredient that helps unclog pores and prevents breakouts. When used together, these two ingredients can dry out your skin and cause irritation.

Retinol and alpha hydroxy acids
Retinol is a powerful anti-aging ingredient that boosts collagen production and improves the appearance of wrinkles. Alpha hydroxy acids are exfoliating ingredients that help improve the appearance of fine lines, wrinkles, and dark spots. When used together, these two ingredients can cause irritation.

Final takeaway

As you can see, there are certain skincare ingredients that should not be mixed because they can cause irritation or other problems for your skin. So next time you’re trying out a new product, take a look at the label to see if there are any ingredients on this list that you should avoid mixing with other products. By doing so, you’ll help keep your skin healthy and happy!

About author

Selma Durmo M. Pharm

“As far as I can remember I have always struggled with sensitive skin. The issues culminated in my mid-twenties when I started having rosacea flares and redness. My personal quest for effective, safe solutions took a professional turn, and I was given the opportunity to apply my (Pharma) background in developing a new skin friendly product line. My goal was to create something new, a clinically proven sustainable skincare brand. This science backed probiotic skincare derived technology is a product of years of research and innovation in personal care products. Metabiotics contain naturally produced hyaluronic acid, lactic acid, SMase, lipoteichoic acid, over 40 peptides and enzymes. All assigned with specific tasks for activating the skins native repair mechanisms.” 

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Following the principles of Clean Beauty, we have joined the dedicated stream of safe, non-toxic beauty enthusiasts.

Our products contain carefully selected hypoallergenic ingredients suitable for sensitive and reactive skin.

We’re committed to formulating with natural, organically-derived, and skin-friendly synthetics while excluding popular “good feeling” and potentially harmful compounds to provide the best skincare solutions.

“It is easy to get hooked on conventional products, with inviting perfumes and the instantly pleasant skin feeling. The sooner you understand that those sensations are short-lived the better! Choose Clean Beauty and allow the science backed ingredients time to work wonders on your skin.”

Cinically proven

Our products’ superiority has been proven in a controlled study on 50 volunteers where it was shown that four-week product use leads to a significant increase in skin moisture levels (39%), increased skin elasticity (50%), and a decrease in the appearance of wrinkles (23%).

Other beneficial effects include decrease in skin sensitivity, increase in skin cleanliness, evenness of the skin tone, decrease in acne formation.

This study serves as proof of the skin’s gradual return of its protective layer, integrity, and balance. All study results have been published in a peer reviewed journal as well as the full study report.

“Putting all science aside, we are most proud of our users’ testimonials. All tested volunteers claimed visible and tangible improvement in skin feel and appearance.”


The greatest breakthrough discovery we stumbled upon is that skincare and cosmetics should not be sensational.

Personal care should be comprehensive, accessible, and efficient, just as all solutions that come from nature are.

We are often faced with labels such as anti aging skin care, organic skin care, natural skincare products, which lack the necessary explanation… What do these phrases actually mean?

“Grown tired of all the misleading, incomprehensive, irrelevant information used in the beauty industry we decided to stick to a no-nonsense approach. It is what it is, and skin care is not magic! It requires commitment, patience and understanding your skins’ needs.”


We are dedicated to neutralizing our negative impact on the environment as much as possible and have joined the stream of sustainable skincare brands. We’re taking you on for the ride (we’ve even packed the goodies)!

To help minimize our carbon footprint, for every product order a tree will be planted thanks to our amazing planters at One Tree Planted. It’s estimated that a mature tree nullifies around 20lbs of CO2 a year.

We’re doing our best to reuse, reduce and recycle. Wishing to inspire a circular economy we have partnered up, to create a customized recycling program. Collect three empty plastic packages to receive your Anbiome Recycling Envelope and follow the instructions on how to take part in our recycling mission. 

Your good deed shall be rewarded. For every three products recycled you receive one product gift!


Today’s trends in skincare require the use of synthetic active ingredients which interact with the skin. Our approach is to distinguish natural alternatives, which mimic the skins native repair mechanism and are more efficient and ecologically sound.

Translating solutions from nature into industrial settings is hardly an easy task, but it’s one we enjoy undertaking.

We have screened 500+ different wild probiotic strains from the nature, to find the most powerful ones.

Special fermentation process was developed to harvest powerful molecules (HA, LTA, SMase, LA and 40 peptides).

Result is the composition of native signal components and molecules that keep the skin balanced, healthy and protected.